Many babies who are exposed to this medication during pregnancy are born healthy with normal growth and development. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. This page includes the following topics and synonyms. Fetal valproate syndrome nord national organization for. Withdrawalsymptoms duringthe neonatalperiodare extremelycom. Sep 22, 2017 fetal valproate syndrome fvs may occur if a developing baby is exposed to valproic acid during pregnancy. It is not well known, and i would love to hear more about it. Google scholar ardinger hh, atkin jf, blackston rd, elsas lj, clarren sk, livingstone s, flannery db, pellock jm, harrod mj, lammer ej, et al.
It was only for a short time period, he didnt even need rescusitation. Pdf fetal valproate syndrome results from prenatal exposure to valproic acid. It is characterised by a distinctive dysmorphic facies and a cluster of minor and major anomalies, as well as developmental and behavioural abnormalities. Naturalhistory pregnancy usually proceeds uneventfully and there is noincreasedincidence ofinstrumental delivery or birth asphyxia. If you know of any helpful links that you think we should share on this blog site, please send us a comment with the link address and we will make a nice tidy list of some of the most helpful and informative sites to visit with regards to. Fetal valproate syndrome is a disorder caused by exposure in the womb to certain prescription drugs.
Fetal valproate syndrome fvs is diagnosed when an individual has a recognizable pattern of facial features, specific malformations, medical or developmental problems in the context of in utero exposure to valproate and following exclusion of other conditions dean et al. Its basically a rare condition caused by my mum taking sodium valproate for a medical condition while pregnant with me. Sep 22, 2017 fetal valproate syndrome fvs is often suspected in an infant who has one or more of the signs and symptoms associated with fvs and whose mother reports having taken valproic acid during the pregnancy. A rare teratogenic disease due to embryofetal exposure to valproic acid vpa and. Antenatal exposure to this drug can cause fetal valproate syndrome fvs. The use of valproic acid vpa monotherapy in the 1st. Diagnosis and management of individuals with fetal. Fetal valproate syndromefetal anticonvulsion syndrome.
The european medicines agency has restricted its use in women due to the increased risk of disabilities in children exposed to valproate in the womb foetal valproate syndrome. There have been several reports of congenital malformations in the offspring of mothers who took valproic acid vpa during pregnancy as a treatment for. More rarely, with several other defects, including a valproate syndrome. Evidence summaries a pivotal, international, randomised, doubleblind, efficacy and safety trial of sodium valproate in paediatric and adult patients with wolfram syndrome. One of the best delineated examples of harmful fetal effects is the fetal valproate syndrome fvs, comprising typical facial features, developmental delay, and a variety of malformations such as neural tube defects, cardiac and gastrourinary malformations, and limb defects winter et al. Fetal valproate syndrome cuillier f, md,fernet a, md,alessandri jl, md,samperiz s. In utero exposure to valproate increases the risk of. The code is valid for the year 2020 for the submission of hipaacovered transactions. They found that he had what was called fetal valproate.
Have a look at things that other people have done to be happy with fetal valproate syndrome world map of fetal valproate syndrome view more. Verification of the fetal valproate syndrome phenotype. Fetal valproate syndrome fvs is a rare condition that is caused by exposure of the unborn baby to valproic acid or sodium valproate dalpro, depakene, depakote, depakote sprinkle, divalproex, epival, myproic acid during the first three months of pregnancy the first trimester. Tabled 08 may 20 2014 session that this house notes with concern the recent refusal by the minister for care and support of a public inquiry into why information was withheld concerning the disastrous way in which sodium valproate has. Fetal anti convulsant syndrome is an umbrella term for a host of different epilepsy medications taken during pregnancy that have had an effect on the baby in utero. Epilepsy is a common disorder and exposure to antiepileptic drugs during pregnancy increases the risk of teratogenicity. Intellectual functioning in clinically confirmed fetal. Become ambassador and add your answer icd9 and icd10 codes of fetal valproate syndrome your answer.
Hiilesmaa vk, teramo k, granstrom ml, bardy ah 1981. Valproic acid or valproate is a wellrecognized potent teratogen. First delineated in 1984 by diliberti et al,1 fvs is characterised by a pattern of major and minor malformations and neurodevelopmental problems together with a distinctive facial. It is characterized by distinctive facial appearance, a cluster of minor. A clinical diagnosis of fetal hydantoin syndrome secondary to in utero phenytoin exposure was considered.
A consistent facial phenotype was observed in all seven in addition to other birth. Prenatal exposure of mother to valproate vpa causes teratogenic effects in the fetus, namely fetal valproate syndrome fvs. Fetal valproate syndrome hatice mutlualbayrak a, cahide bulut b,hu. Of the five children described by hanson and smith, only one was exposed to phenytoin monotherapy. But holden james stopped breathing when he was 1 day old. A consistent facial phenotype was observed in all seven in addition to other birth defects in four. Jul 11, 2019 fetal hydantoin syndrome is a drugrelated embryofetopathy that can occur when an embryofetus is exposed to the anticonvulsant drug.
Many babies who are exposed to this medication during pregnancy are born healthy with normal growth and. The features of the fetal valproate syndrome are epicanthic folds, flat nasal bridge, broad nasal base, anteverted nostrils, shallow philtrum, thin upper lip with thick lower lip, and, in some cases, ridging of the metopic suture, congenital heart defect, postaxial polydactyly, and hypospadias winter et al. Prenatal sonographic diagnosis of fetal valproate syndrome. It is characterized by distinctive facial appearance, a cluster of minor and. There is no test that can confirm the diagnosis of fvs, instead other possible causes of the signs and symptoms seen in the baby must be ruled out. Google scholar jagerroman e, deichl a, jakob s, hartmann am, koch s, rating d, steldinger r, nau h, helge h. The fetal valproate syndrome the fetal valproate syndrome diliberti, john h farndon, peter a dennis, nicholas r curry, cynthia j. Mar 08, 2016 fetal valproate syndrome is a disorder caused by exposure in the womb to certain prescription drugs. Fetal valproate syndrome radiology reference article. Antenatal use of anticonvulsant valproic acid can result in a wellrecognized. The use of valproic acid vpa monotherapy in the 1 st trimester of pregnancy was associated with significantly increased risks of major and minor malformations, including a 20fold increase in neural tube defects ntds, cleft lip and palate, cardiovascular abnormalities, genitourinary defects, developmental delay, endocrinological disorders, limb defects, and. Depakote in pregnancy fetal valproate syndrome learn. There have been several reports of congenital malformations in the offspring of mothers who took valproic acid vpa during pregnancy.
Facs association fetal anti convulsant syndrome association. Fetal valproate syndrome fetal valproate syndrome chessa, l iannetti, p neri, giovanni 19860601 00. Management of congenital anomalies should follow standard treatment protocols. Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid. A 3monthold male child admitted with complaints of breathlessness since 3 days with fever. Fetal valproate syndrome fvs is characterized by minor craniofacial anomalies, major organ malformations, and developmental delay. Fetal valproate syndrome, american journal of medical. We report on a patient who has a clinical phenotype compatible. The mother was diagnosed with infantile epilepsy at 1 year of age. She also had 3 spontaneous firsttrimester abortions during those 3 years. Antenatal exposure to this drug can cause fetal valproate syndrome fvs, which is a constellation of distinctive dysmorphic. Exposure to valproic acid during first trimester can result in fetal valproate. Omim entry 609442 valproate embryopathy, susceptibility to. As all our cases had the typical facial appearance of fetal valproate syndrome fvs, it was clear that this developed when the fetus was exposed to between 500 mgd and mgd.
I have a diagnosis of highfunctioning autism but my overall condition is fetal valproate syndrome. Clinical presentation there is a wide clinical spectrum which includes neural tube. Fetal valproate syndrome fvs is diagnosed when an individual has a recognizable pattern of facial features, specific malformations, medical or. Fetal valproate syndrome fvs is a potential embryopathy that can occur as a result from maternal intake of valproic acid sodium valproate during pregnancy. Fetal hydantoin syndrome is a drugrelated embryofetopathy that can occur when an embryofetus is exposed to the anticonvulsant drug. Fetal valproate syndrome fvs results from teratogenic effects of valproic acid exposure in the prenatal period. Icd10 code of fetal valproate syndrome and icd9 code.
Jagerroman e, deichl a, jakob s, hartmann am, koch s, rating d, steldinger r, nau h, helge h. Sodium valproate epilim is a medication used to treat epilepsy and bipolar disorder. It should be noted that the feature of downturned angles of the mouth was infrequently specified in the literature on similar cases. The fetal valproate syndrome diliberti 1984 american. Fetal head growth retardation associated with maternal antiepileptic drugs. Children affected by sodium valproate epilepsy society. Fetal valproate phenotype is recognisable by mid pregnancy. Older aeds such as valproate and phenobarbital are associated with a higher risk of major malformations in the fetus than newer aeds like lamotrigine and levetiracetam. It is a rare condition caused by my mum taking sodium valproate during her pregnancy. Living with fetal valproate syndrome can be difficult, but you have to fight to try to be happy.
Our patient was a female infant who was born to a 27yearold nulliparous japanese woman with epilepsy. Exposure to valproic acid during first trimester can result in fetal valproate syndrome fvs, comprising. Here, we report a case of a 3monthold baby with facial dysmorphism, as a case of fetal valproate syndrome fvs based on the phenotype and maternal use of valproic acid during the antenatal period. Im in my midtwenties, i live in west london, currently working as a customer service assistant. Departments of pediatrics and medical genetics, emanuel hospital, department of pediatrics, oregon health sciences university, portland. Im doing well though, i live independently and i have a parttime job. Fetal valproate syndrome cuillier f, md,koenig, md,alessandri jl, md,bideault j fetal valproate syndrome cuillier f, md,fernet a, md,alessandri jl, md,samperiz s fetal valproic acid exposure syndrome philippe jeanty, md, phd,sandra r silva, md. Reports of other malformations followed, and in 1984 the first series of seven children affected by the fetal valproate syndrome fvs was published by di liberti et al. In this report, we describe a case with typical features of fetal valproate syndrome fvs.
In agreement with previous authors, we feel that there is a distinctive fetal valproate phenotype. Fetal valproate syndrome results from prenatal exposure to valproic acid. Valproic acid, also known as valproate, is a medication that is often used to treat epilepsy, bipolar disorder, and migraines. The aim of this study was to evaluate the clinical features and frequency of autistic disorder or asperger syndrome as. Prevalence of fetal valproate syndrome fvs is unknown. Fetal valproate syndrome fvs describes a constellation of features that has been recognised in a number of children exposed to valproic acid vpa in utero.
It is characterized by distinctive facial appearance, a cluster of minor and major anomalies and central nervous system dysfunction. Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic. Fetal valproate syndrome fvs may occur if a developing baby is exposed to valproic acid during pregnancy. Fetal valproate syndrome fvs is a rare condition that is caused by exposure of the unborn baby to valproic acid or sodium valproate dalpro, depakene, depakote, depakote sprinkle, divalproex, epival, myproic acid during the first three months of. Fetal valproate syndrome genetic and rare diseases. When my son was born, on december 31st, 2009 we were elated to have a new child just in time for a new year. Please feel free to share your experiences with this syndrome. If you have a childchildren who have been diagnosed with fetal valproate syndrome and would be happy for them to form part of the montage to be broadcast on the bbc news channels, please email their photo to nicola. The fetal valproate syndrome, american journal of medical. Handbook of genetic counselingfetal valproate syndrome. Epilim, depakote, convulex, episenta, epival, kentlim. Get a printable copy pdf file of the complete article 1. Prenatal exposure to valproate is associated with an increased risk of neurodevelopmental deficits bromley et al.
Vpa treatment was set at a dose of mg daily by an. Our patient was a female infant who was born to a 27yearold nulliparous japanese woman. Full text get a printable copy pdf file of the complete article 9k, or click on a page image below to browse page by page. Sep 15, 2017 if you have a childchildren who have been diagnosed with fetal valproate syndrome and would be happy for them to form part of the montage to be broadcast on the bbc news channels, please email their photo to nicola. Organisation for anticonvulsant syndrome valproate epilim. One of the most commonly prescribed teratogenic drug classes during pregnancy is anticonvulsant medications, which are required owing to the risks posed by seizures to both the mother and child. Fetal valproic acid exposure syndrome philippe jeanty, md, phd,sandra r. Children will not be named but will form part of a similar. References diliberti jh, farndon pa, dennis nr, curry cjr 1984.
We report a case of fetal valproate syndrome rarely diagnosed by prenatal sonographic examination. I have highfunctioning autism, mild learning difficulties, mild speech problem and mild scoliosis. Fetal hydantoin syndrome fhs among the many dysmorphic findings associated with this syndrome, hypoplasia and irregular ossification of the distal phalanges was originally believed to be the single most characteristic feature. For rose, the symptoms included cleft lip and palate, a hole in her heart, specific facial and body features, and sticky ear sometimes causing hearing loss. A case of fetal valproate syndrome with new features expanding the phenotype article pdf available in saudi medical journal 302.